Moriana "Roncoleukin" ke oa sehlopha sa li-immunomodulatory tse tsebahalang haholo ebile li theko e tlase tse lefellang khaello e matla ea "interleukin-2" e sa feleng, e lumellang ho hlahisa litholoana tsa eona ka lebaka la likarolo tsa mantlha. Moriana ona, o atisang ho beoa ke lingaka tsa liphoofolo, ke sebopeho se sebetsang le se sebetsang sa "interleukin-2" e tloaelehileng ea motho.
Ho beha moriana
Seo ho thoeng ke bathusi ba lisele tsa T, tse emeloang ke li-lymphocyte tse khethehileng, li ikarabella bakeng sa tlhahiso ea interleukin 'meleng.... Ntho e thehoa joalo ka karabelo ea 'mele ho livaerase tse kenang. IL e hlahisitsoeng e hlohlelletsa tlhahiso ea li-T-killers, mme ka nako e ts'oanang e eketsa ts'ebeliso ea ntho e kahare ho bathusi ba T. Likhetho tsa molao-motheo oa ketso ea IL li na le bokhoni ba ho ikamahanya habonolo le li-receptor tse ikhethang tsa lisele tsa antigen tse kenang 'meleng oa batho eseng feela empa le liphoofolo.
Lithethefatsi "Roncoleukin" li sebetsa maemong a mangata:
- maemo a septic a tsamaeang le khatello ea mmele;
- liphetoho tsa septic tsa mofuta oa kamora ho sithabetsa;
- tšoaetso ea maqeba kamora ho sithabela haholo;
- dermatitis, dermatoses, eczema, liso tsa ka maleng;
- mathata a ho buoa le a pelehi le mafu a basali.
- ho chesa ha mocheso le lik'hemik'hale;
- osteomyelitis;
- pneumonia e matla, pleurisy le bronchitis;
- hangata mafu a phefumolohang khafetsa;
- mpa le peritonitis;
- pancreatic necrosis le pancreatitis e matla;
- lefuba le hatelang pele ka potlako;
- kankere liphetoho dinama tse nyenyane tse renal;
- likokoana-hloko, baktheria, fungal le tomoso.
Kahoo, interleukin e na le phello e ntle haholo tlhahiso ea lisele tse sireletsang 'meleng oa phoofolo, e emeloang ke li-monocyte, macrophages, B le T lymphocyte. Sesebelisoa se sebetsang se ntlafatsa bokhoni ba lisele tsa Langerhans, tse nang le li-macrophages tsa intraepidermal.
Hoa thahasellisa! Likarolo tsa litlhare tsa moriana "Roncoleukin" li baka tšenyo e potlakileng ea hoo e batlang e le microflora efe kapa efe e kenang 'meleng oa phoofolo, hape e fana ka ts'ireletso e ts'epahalang khahlano le libaktheria, livaerase, tomoso le likokoana-hloko tsa fungal.
Lipontšo tsa tšebetso ea babolai ba T ka kotloloho li ipapisitse le recombinant interleukin-2 (rIL-2), sebopeho se sebetsang le se sebetsang sa li-interleukin-2 tse sa feleng. Har'a lintho tse ling, ntho ena haholo eketsa ho hanyetsa 'mele oa lisele tse ling hlahala, potlakisa dithulaganyo ba bonoa ba bona le timetso e latelang.
Sebopeho, foromo ea tokollo
Immunomodulator "Roncoleukin" ke mokhoa o bonolo oa ho sebelisa o sebelisang mokhoa oa:
- lyophilized phofo bakeng sa tharollo - 1 ampoule;
- recombinant interleukin-2 ea motho ka 0,25 mg, 0.5 mg le 1 mg kapa 250 sekete, 500 sekete kapa 1 milione IU, ka ho latellana.
Ba amohelang sethethefatsi se itšireletsang mafung:
- sodium dodecyl sulfate solubilizer - 10 mg;
- ho tsitsisa D-mannitol - 50 mg;
- fokotsa moemeli dithiothreitol - 0,08 mg ,.
Lebokose le na le li-ampoule tse hlano, hammoho le thipa e bonolo ea ampoule. Phofo e boima le e nang le lyophilized, e kopantsoeng ka letlapeng le lesoeu kapa le bosehla, le nang le hygroscopic, le qhibilihang habonolo ha le sebelisa tharollo ea isotonic sodium chloride.
Litaelo tsa tšebeliso
Kajeno ho na le mekhoa e fapaneng ea ho sebelisa moriana oa sejoale-joale oa ho itšireletsa mafung, empa litekanyetso le bolelele ba nako ea kalafo bo lokela ho khethoa ke ngaka ea liphoofolo. Lithethefatsi li tsamaisoa ka mokhoa o koahelang kapa ka methapo, ka linako tse ling tsa lihora tse 24 kapa tse 48.
Tsela e tloaelehileng ea kalafo ke liente tse peli kapa tse tharo. Palo e tloaelehileng ke 10,000 IU / kg. Kalafo ea mofets'e e kenyelletsa tšebeliso ea liente tse hlano, 'me thupelo e phetoa kamora nako e ka etsang khoeli. Immunomodulatory "Roncoleukin" e boetse e laeloa nakong ea kapa ka morao kapa ka mora radiation le chemotherapy.
Mekhoa e tloaelehileng, e amoheloang ka kakaretso ea ho sebelisa sethethefatsi "Roncoleukin" ho liphoofolo tse ruuoang lapeng tse maoto a mane:
- Ts'ebeliso ea immunomodulator joalo ka ente e thusang le ho imolla khatello ea maikutlo nakong ea lits'ebetso tse fapaneng ke tekanyetso e le 'ngoe ea 5000 IU / kg;
- Phekolo ea mafu a letlalo e etsoa ka ho khethoa ha liente tse tharo ho isa ho tse hlano ka tekanyo ea 10,000 IU / kg;
- Thibelo ea mafu a baktheria, vaerase le fungal e kenyelletsa tsamaiso e ka tlasa letlalo ka sekhahla sa 5000 IU / kg ka sebopeho sa ente e le 'ngoe kapa tse peli ka nako ea matsatsi a 2;
- bakeng sa pathologies ea tsamaiso ea ho ntša metsi, ho kgothaletswa hore o e sebelise kalafo e rarahaneng ka mofuta oa liente tse peli kapa tse tharo tsa 10,000 IU / kg ka nako ea letsatsi le letsatsi;
- bakeng sa lefu la renal polycystic, moriana o sebelisoa kalafong e rarahaneng ka mofuta oa liente tse hlano tsa 20,000 IU / kg ka nako ea matsatsi a mabeli.
Mehato ea thibelo e etsoa habeli ka selemo ka linako tse ling tsa likhoeli tse tšeletseng... Ha cystitis le urolithiasis moriana immunomodulatory lokela ho tsamaiso intravesically kapa intercystially. Tsela ea kalafo e phetoa khoeli e le 'ngoe ka mor'a hore e entsoe. Hape, lithethefatsi "Roncoleukin" e sebelisetsoa ho lokisetsa liphoofolo tse ruuoang lapeng bakeng sa lipontšo. Tabeng ena, ho kgothaletswa ho sebelisa tekanyetso ea 5000 IU / kg, e tsamaisoang habeli ka nako ea letsatsi le letsatsi, empa ente ea ho qetela e lokela ho sebelisoa bonyane matsatsi a mabeli pele ho pontšo.
Hoa thahasellisa! Ketsahalong e 'ngoe le e' ngoe e khethehileng ea ho khethoa ha immunomodulator, mokhoa oa kopo o lokela ho lateloa, mme tlolo ea molao ona e ka baka phokotso e kholo ts'ebetsong ea moriana.
Immunomodulator "Roncoleukin" e kgothaletswa hantle e le mokhoa o mocha oa kalafo ea tlhokomelo bakeng sa liphoofolo tse ruuoang lapeng tse fokolang kapa tsa khale. Bakeng sa morero ona, lingaka tsa litleliniki tsa bongaka ba liphoofolo li fana ka litlhare ka kotara ka kotara e le 'ngoe kapa tse peli tsa 5000-10000 IU / kg. Tšusumetso ea ho itšireletsa mafung a tlhaho ka har'a malinyane a nang le ts'oaetso e fokolang ea ho anyesa e kenyelletsa ente e habeli ea molomo kapa e katang ka sekhahla sa 5000 IU / kg ka nako ea letsatsi le letsatsi.
Litlhaloso
Le ha e le hantle hore moriana le "prophylactic" Roncoleukin "hangata e mamelloa hantle ke liphoofolo tse ruuoang lapeng, ka linako tse ling liphetoho tse mpe li hlokomeloa ka ts'ebeliso ea tsona. Litemoso tse ka sehloohong tsa lehae tseo ts'ebeliso ea moriana o thibelang ho itšireletsa mafung e sa khothaletsoang e kenyelletsa:
- haeba phoofolo e hanana le tomoso, e leng karolo ea lithethefatsi;
- mafu a itšireletsang mafung;
- pulmonary pelo hloleha ea lengolo la boraro;
- Ho hloleha ha pelo ka matla
- liso tsa boko tsa maemo a fapaneng a ho rarahana;
- qetellong sethaleng renal cell carcinoma;
- nako ea bokhachane.
Ho liphoofolo tse ling, lithethefatsi li na le hypersensitivity e matla haholo. Har'a tse ling, ka tlhokomelo e kholo, moriana o fuoa likatse tse nang le mathata a amanang le boemo ba liphio kapa sebete.
Mehato ya tlhokomelo
Nakong ea ho itokisa, kakaretso ea nako ea ho felisoa ha moriana ha e fete metsotso e meraro... Tharollo e lokisitsoeng ea ho itšireletsa mafung e lokela ho ba e se nang mmala, e bonaletsang, e se nang litšila.
Lithethefatsi "Roncoleukin" li tsamaisana ka botlalo le litokisetso tse ling tse ngata tsa meriana. Leha ho le joalo, ha u sebelisa immunomodulator, melao e bonolo e latelang e tlameha ho lateloa:
- Ho thata haholo ho kenya "Roncoleukin" hammoho le tharollo e nang le tsoekere, hobane maemong ana lits'ebetso tsa lithethefatsi li fokotsehile haholo;
- ho thibetsoe ho fana ka nako e le 'ngoe "Roncoleukin" ka lithethefatsi tsa corticosteroid bakeng sa ts'ebeliso ea sistimi kapa ea lehae.
Ts'ebetsong ea ho kenya tšebetsong melao ea kalafo e behiloeng, ho khothaletsoa ka matla ho boloka litekanyetso tse bontšitsoeng ke ngaka ea liphoofolo. Ho seng joalo, khahlano le semelo sa kalafo e etsoang, mocheso oa 'mele oa phoofolo ea lapeng o ka nyoloha kapa ho hloleha ha morethetho oa pelo.
Bohlokoa! Latela ka tatellano tatellano, hammoho le kalafo ea kalafo e laetsoeng ke ngaka ea liphoofolo, ntle le ho tlola liente, hobane ho seng joalo katleho ea litlamorao tsa lithethefatsi e fokotseha haholo.
Ka bongata ba tharollo ea immunomodulatory e keneng maling, matšoao a ho fetela holimo a tlameha ho emisoa ka lithethefatsi tse khahlanong le ho ruruha le li-analeptics tse khethehileng.
Litla-morao
Maemong ao sethethefatsi se sebelisoang ka tekanyetso e lekaneng, hape se fuoa phoofolo ea lapeng ka ho sebelisa litsela tse khothalletsoang, litla-morao hangata ha li tsejoe. Ente e ka tlasa letlalo ea sethethefatsi "Roncoleukin" ka linako tse ling e ka tsamaea le maikutlo a bohloko a nako e khuts'oane ka "ho chesa".
Ka tlolo e kholo ea melao ea ts'ebeliso ea "immunomodulator", hang kamora kenyelletso, ho ba le keketseho ea mocheso oa lehae le oa kakaretso, hammoho le keketseho e sa tsejoeng haholo ea sekhahla sa pelo. Ho fetella ho hoholo ha lethal dose ha ho fanoa ka methapo ho ka etsa hore phoofolo e hlahise tšabo ea lefu la anaphylactic kapa lefu. Moriana o senotsoeng o kentsoeng ka mokhoa o ikhethileng o tsosa lits'ebetso tsa lehae tsa ho ruruha.
Litšenyehelo tsa Roncoleukin bakeng sa likatse
Litsenyehelo tsa recombinant interleukin-2, sebopeho se sebetsang le se sebetsang sa li-interleukin-2 tse sa sebetseng, tse arohaneng le lisele tsa tomoso ea sebaki e seng ea likokoana-hloko Saccharomyces servisiae e nang le lefutso le kentsoeng la motho, li theko e tlase haholo. Theko ea karolelano ea lithethefatsi tse joalo e fapana ho latela mohopolo oa ntho e sebetsang mme hajoale ke:
- Li-ruble tse likete tse 50 tsa IU - 190-210 ruble;
- 10000 IU - li-ruble tse 240-260;
- 250 tse likete IU - 340-360 li-ruble;
- 500,000 IU - 610-63- li-ruble.
Ho kgothaletswa ho reka moloko o mocha o sebetsang hantle oa ho itšireletsa mafung li-pharmacy tsa bongaka ba liphoofolo. Ha u reka, etsa bonnete ba hore u sheba boleng ba moriana, hammoho le letsatsi la ho felloa ke nako.
Litlhahlobo tsa Roncoleukin
Moemeli oa ho itšireletsa "Roncoleukin" o laeloa ke lingaka tsa liphoofolo eseng feela ho liphoofolo tse ruuoang lapeng tse kholo, empa hape le ho malinyane a sa tsoa tsoaloa, liphoofolo tsa khale le tse fokolang. Ketso ea mantlha ea sethethefatsi sena e ipapisitse le ts'usumetso ea sesole sa 'mele,' me ka lebaka la ts'ireletso e eketsehileng, 'mele oa phoofolo o fumana ho hanela likokoana-hloko tse fapaneng, libaktheria, li-fungus le likokoana-hloko tse ling tsa likokoana-hloko.
Joalokaha litlatsetso tsa beng ba likatse li bontša, linyeoe ha immunomodulator e netefalitse ts'ebetso ea tsona e phahameng li fapane haholo.... Sesebelisoa se ipakile hantle kalafong ea panleukopenia, parvovirus enteritis le maloetse a mang a tšoaetsanoang, hape e iponahalitse hantle kalafong ea mafu a phefumolohang. Ka lebaka la ts'ebeliso, lits'ebetso tsa nchafatso li qalile 'me pholiso ea maqeba a thata le a sa foleng a nako e telele a potlakile.
Ho ea ka lintho tse ngata tse hlokometsoeng, lithethefatsi li thusa ho fokotsa kapele phoofolo ea lapeng ho tsoa ho stomatitis, gingivitis le maloetse a mang a molomo, e loketse ho phekola mafu a letlalo (eczema le dermatitis), hammoho le conjunctivitis. Hammoho le litokisetso tse ling tsa meriana kapa litlhare tsa setso, immunomodulator "Roncoleukin" e sebetsana hantle le ho chesa le serame, maqeba a lacerated, hammoho le ho robeha le matetetso a matla.
Hoa thahasellisa! Morao tjena, lithethefatsi li se li laetsoe ka mokhoa o eketsehileng nakong ea ho enta 'me li thusa ho theha boits'ireletso bo matla ho mafu a atileng haholo a vaerase.
Lithethefatsi "Roncoleukin", ho latela litsebi tsa bongaka ba liphoofolo, li netefalitsoe ho hatella tšebetso ea likokoana-hloko tse ngata tse kotsi le ho potlakisa ts'ebetso ea ho hlaphoheloa ha phoofolo e maoto a mane. Ke ka lebaka lena immunomodulator joalo hangata e behiloeng hammoho le lithethefatsi, tseo ketso ea tsona e ikemiselitseng ho felisa lisosa tsa liphetoho tsa mafu kapa matšoao a tsona ka kakaretso.
Ho tla boela ho be monate:
- Maxidine bakeng sa likatse
- Milbemax bakeng sa likatse
- Pirantel bakeng sa likatse
- Gamavite bakeng sa likatse
Ho tsa bongaka ba bongaka ba liphoofolo, li-analogues tsa sethethefatsi "Roncoleukin" li ka sebelisoa hantle, tse kenyeletsang "Proleukin" le "Betaleukin". Leha ho le joalo, leha e na le katleho e phahameng le e ke keng ea latoloa, ke immunomodulator "Roncoleukin" eo e leng ea moloko o mocha oa lithethefatsi, ka hona lingaka tsa bongaka ha li eletse ho boloka bophelo ba liphoofolo le ho fana ka moriana ona oa sejoale-joale.
